Ariana Boswell

All articles by Ariana Boswell

• Cogent submits New Drug Application for bezuclastinib in nonadvanced SM

  Cogent Biosciences submitted a New Drug Application to the FDA for bezuclastinib in non-advanced SM, with future submissions planned in 2026.

• How to prepare for a bone marrow biopsy

  Spacing out your preparation can help make the process feel less overwhelming.

• Panel offers specialized guidelines for epinephrin use in SM

  A group of experts in anaphylaxis offered recommendations for epinephrin use in different patient populations, including those with SM.

• New data shows bezuclastinib lowers mast cell burden in advanced SM

  Cogent Bioscience announced that their trial of bezuclastinib in patients with advanced SM showed the drug to be safe and effective.

• What is a mast cell?

  Mast cells, which drive SM, are a type of white blood cell essential to the immune system.

• Avapritinib may alleviate skin symptoms in patients with indolent SM long-term

  Patients with indolent SM who took avapritinib saw significant improvements in itching, flushing and skin spots that lasted for three years.

• Patients with SM may experience cardiovascular symptoms

  Individuals with mast cell diseases like SM may experience cardiac, vascular and bleeding symptoms that need specialized care.

• Combining genetic and blood testing may improve SM diagnosis

  Researchers developed an algorithm that helps differentiate SM from hereditary alpha-tryptasemia, a condition with many overlapping symptoms.

• What is KIT D816V mutation testing?

  KIT D816V mutation testing is simple – all it takes is a blood draw.

• Case report: Severe SM and KIT mutation in an infant

  This study represents the first known case of a patient with SM with detectable KIT D816V mutations in all cells of the body.