Ryner Lai, MBBS

All articles by Ryner Lai, MBBS

• Case report highlights complexity of insomnia in indolent SM

  Some therapies in SM may lead to complications such as insomnia.

• New method of KIT D816V testing shows promising results

  This study highlights the efficacy of a new method developed for the genetic diagnosis of SM.

• Subtypes explained: What is SM-AHN?

  One in five patients with SM have the SM-AHN subtype.

• Researchers examine how nonadvanced SM symptoms affect quality of life

  A variety of symptoms in nonadvanced SM are associated with a poor quality of life and show an unmet need for better symptom management.

• Can processed foods trigger systemic mastocytosis symptoms?

  Many find that specific types of processed foods trigger their symptoms, but what triggers symptoms in one patient might be completely fine for another.

• Study examines potential treatment for mast cell-mediated allergic responses

  EtCC plays a significant role in downregulating immune responses, which is important in diseases such as systemic mastocytosis.

• Subtypes explained: What is mast cell leukemia?

  Given that MCL is a rare subtype of an already rare disease, there is much about it that is poorly understood.

• Clinical trial examining MGD024 in advanced SM

  Researchers are currently recruiting patients for a trial assessing an investigational therapy for use in treatment-resistant blood cancer.

• Why are cancer treatments sometimes used for systemic mastocytosis?

  In some cases, mast cells proliferate and infiltrate organs in a cancer-like manner.

• How does systemic mastocytosis affect the digestive system?

  When mast cells infiltrate the gut wall, they can release chemicals that can harm.