Advanced SM

In these subtypes of SM, mast cells begin to damage organs. Advanced SMAdvanced SM In these subtypes of SM, mast cells begin to damage organs. Advanced SM includes the subtypes aggressive SM, mast cell leukemia and SM with an associated hematological neoplasm. includes the subtypes aggressive SMAggressive SM A subtype of advanced SM marked by a high mast cell burden that leads to organ damage. Aggressive SM accounts for less than 10% of SM cases., mast cell leukemiaMast cell leukemia The most severe subtype of SM, caused by the rapid buildup of immature mast cells in the bone marrow and blood. Mast cell leukemia accounts for less than 5% of SM cases and has a poor prognosis. and SM with an associated hematological neoplasmSM with an associated hematological neoplasm A form of advanced SM and the second-most common subtype of SM overall. In this subtype, SM occurs alongside another blood disorder. Also called SM with an associated myeloid neoplasm..