Ariana Boswell

All articles by Ariana Boswell

• Drug reactions in SM may be less common than previously thought

  Drug-induced reactions such as anaphylaxis are possible in patients with SM, but recent data suggests that the risk is relatively low.

• Advancements in flow cytometry may improve SM diagnosis

  A combination of quantitative and laboratory techniques may be used to improve the diagnosis of SM with flow cytometry, a recent study found.

• Clinical trial examining cancer drug TL-895 for indolent systemic mastocytosis

  A clinical trial is currently underway to determine the optimal dosage of a novel cancer drug in patients with ISM.

• New study examines SM burden from both patient and provider perspectives

  A first-of-its-kind study in Europe identified sources of disease burden as reported by patients with SM and their healthcare providers.

• Sarilumab does not improve quality of life in patients with indolent SM

  A clinical trial of 16 patients with indolent SM found that sarilumab does not significantly improve quality of life.

• Case report: Patient diagnosed with rare, aggressive form of SM

  A patient who was diagnosed with mast cell leukemia, a rare form of SM, experienced symptom relief with methylprednisolone treatment.

• Case report: Patient develops SM after germ cell tumor treatment

  A 9-year-old girl underwent a stem cell transplant after being diagnosed with SM following treatment for a germ cell tumor.

• Case report: Aortic valve replacement failure in patient with aggressive SM

  A case report describes a patient who experienced two failed transcatheter aortic valve replacements, likely related to her underlying SM.

• Duplex sequencing uncovers additional responders to avapritinib

  Duplex sequencing can reveal KIT mutations in a subset of patients with SM who do not have detectable mutations by ddPCR, a study found.

• Rare Disease Day: Why it matters and how to get involved

  Rare Disease Day 2025 aims to uplift the rare disease community and promote greater awareness.