Leonardo Jaimes, MD

All articles by Leonardo Jaimes, MD

• Case report: New KIT mutation identified in a patient with SM

  A case report was recently published describing a man with systemic mastocytosis and a previously unknown KIT mutation.

• Researchers highlight complex mutational profile of SM-AHN

  Systemic mastocytosis with an associated hematologic neoplasm (SM-AHN) appears to have a higher mutational burden than isolated SM.

• Case report: Patient diagnosed with both SM and POTS

  A rare presentation of systemic mastocytosis (SM) alongside postural orthostatic tachycardia syndrome (POTS) was recently reported.

• Rare SM variant linked to new genetic mutations

  Well-differentiated systemic mastocytosis (WDSM), a rare SM variant, was recently associated with previously unknown genetic mutations.

• New study provides insights on how SM impacts the respiratory system

  SM is a risk factor for the development of respiratory symptoms, regardless of whether it presents as indolent SM or advanced SM.

• New program expands access to bezuclastinib for SM

  A new expanded access program (EAP) has been launched for patients with SM, allowing eligible patients to receive bezuclastinib.

• Phase 2 trial explores bezuclastinib for advanced systemic mastocytosis

  A Phase 2 clinical study called Apex is currently evaluating the safety and efficacy of bezuclastinib in patients with advanced SM.

• Researchers identify potential new biomarkers of SM

  Mast cells in patients with systemic mastocytosis (SM) appear to express increased levels of galectin-3 and galectin-8.

• Reporting of SM and other mast cell disorders is rising, study finds

  The use of diagnostic codes for mast cell disorders, such as systemic mastocytosis (SM), appears to be on the rise.

• New data reveals high emotional impact of indolent systemic mastocytosis

  Patients with indolent SM experience significant limitations in their daily lives that directly correlate with symptom burden.