Leonardo Jaimes, MD

All articles by Leonardo Jaimes, MD

• Researchers examine characteristics of organ damage in advanced SM

  A new study provides a detailed snapshot of organ damage in patients with advanced SM at the time of enrollment in clinical trials.

• Case report: Mastocytosis relapse after long-term remission

  A recent case report describes the rare reoccurrence of mastocytosis in an adult patient 40 years after a childhood diagnosis.

• Case study: SM masquerading as severe fainting in a child

  A young girl with severe systemic mastocytosis (SM) experienced recurrent fainting episodes, initially misdiagnosed as reflex syncope.

• Case report: SM found after tropical fruit triggered anaphylaxis

  An unusual case of anaphylaxis following ackee fruit ingestion led to the unexpected diagnosis of indolent systemic mastocytosis (SM).

• New approach helps identify proteins that may predict outcomes in SM

  High-throughput proteomics and machine learning helped uncover new protein signatures with useful prognostic implications in SM.

• New research finds avapritinib helps skin symptoms in advanced SM

  Avapritinib, a selective KIT D816V inhibitor, appears to produce long-term improvements in skin symptoms in patients with advanced SM.

• Case report: SM as hidden cause of recurrent vertebral fractures

  A case of systemic mastocytosis in which recurrent vertebral fractures were the primary symptom was recently reported.

• HT-KIT receives FDA Orphan Drug Designation for SM

  HT-KIT, a precision antisense oligonucleotide (ASO) therapy targeting KIT-driven malignancies and SM, has shown promising results in trials.

• Case report: Patient diagnosed with BMM and skin lymphoma

  A rare case of SM associated with a skin lymphoma was recently reported, and is the only known case of the lymphoma occurring with BMM.

• Blood cell counts could help predict outcomes in SM

  Eosinophil, monocyte and leukocyte counts could correlate with the severity of systemic mastocytosis (SM) and predict outcomes.