Leonardo Jaimes, MD

All articles by Leonardo Jaimes, MD

• Patients with indolent SM have quality of life comparable to that of some cancers

  Patients with indolent systemic mastocytosis appear to have a quality of life comparable to that of patients with lymphoma and leukemia

• Bezuclastinib improves SM symptoms significantly in clinical trial 

  A clinical trial demonstrated that bezuclastinib significantly improved symptoms and biomarkers of systemic mastocytosis.

• Ultrasensitive duplex sequencing improves SM diagnosis

  Ultrasensitive duplex sequencing could improve diagnosis of indolent systemic mastocytosis in patients with low variant allele frequencies.

• Bezuclastinib shows high overall response rates in patients with SM, company says

  Patients with systemic mastocytosis (SM) showed promising overall response rates to treatment with bezuclastinib, its maker announced.

• Some specialists have low awareness of SM, study says

  Some medical specialists lack awareness of systemic mastocytosis (SM) because of its association with various symptoms.

• Patients with SM have a distinct plasma protein profile

  Patients with systemic mastocytosis (SM) have a different plasma protein profile compared to healthy people.

• Bezuclastimib significantly reduced symptoms in nonadvanced SM: company

  Preliminary results showed that patients receiving bezuclastinib had better results than patients receiving a placebo in a clinical trial.

• Study will assess HMA and KIT inhibitors to treat SM subtype

  A new study will examine a treatment for patients with systemic mastocytosis with an associated hematologic neoplasm.

• FDA approves new liquid form of imatinib to treat some forms of SM

  Imatinib is a treatment for patients with aggressive SM without the KIT D816V mutation or having unknown KIT mutational status.

• Study confirms that KIT-inhibitor therapy improves prognosis in advanced SM

  A new prognostic score confirmed that KIT Inhibitors improve outcomes in patients with advanced systemic mastocytosis (SM).