Leonardo Jaimes, MD

All articles by Leonardo Jaimes, MD

• HT-KIT receives FDA Orphan Drug Designation for SM

  HT-KIT, a precision antisense oligonucleotide (ASO) therapy targeting KIT-driven malignancies and SM, has shown promising results in trials.

• Case report: Patient diagnosed with BMM and skin lymphoma

  A rare case of SM associated with a skin lymphoma was recently reported, and is the only known case of the lymphoma occurring with BMM.

• Blood cell counts could help predict outcomes in SM

  Eosinophil, monocyte and leukocyte counts could correlate with the severity of systemic mastocytosis (SM) and predict outcomes.

• Anesthetic strategy tailored to avoid triggers during C-section for a woman with SM

  A recent case report describes the specially tailored anesthetic protocol for a C-section in a woman with systemic mastocytosis (SM).

• Aggressive SM presenting as fever of unknown origin: Case study

  Aggressive systemic mastocytosis (SM) can present with nonspecific symptoms like fever, which can complicate diagnosis

• New data suggests avapritinib is effective in patients with indolent SM long-term

  A new cumulative analysis from the PIONEER trial provides encouraging long-term data on avapritinib for indolent SM.

• Case report: New KIT mutation identified in a patient with SM

  A case report was recently published describing a man with systemic mastocytosis and a previously unknown KIT mutation.

• Researchers highlight complex mutational profile of SM-AHN

  Systemic mastocytosis with an associated hematologic neoplasm (SM-AHN) appears to have a higher mutational burden than isolated SM.

• Case report: Patient diagnosed with both SM and POTS

  A rare presentation of systemic mastocytosis (SM) alongside postural orthostatic tachycardia syndrome (POTS) was recently reported.

• Rare SM variant linked to new genetic mutations

  Well-differentiated systemic mastocytosis (WDSM), a rare SM variant, was recently associated with previously unknown genetic mutations.