Leonardo Jaimes, MD

All articles by Leonardo Jaimes, MD

• Anesthetic strategy tailored to avoid triggers during C-section for a woman with SM

  A recent case report describes the specially tailored anesthetic protocol for a C-section in a woman with systemic mastocytosis (SM).

• Aggressive SM presenting as fever of unknown origin: Case study

  Aggressive systemic mastocytosis (SM) can present with nonspecific symptoms like fever, which can complicate diagnosis

• New data suggests avapritinib is effective in patients with indolent SM long-term

  A new cumulative analysis from the PIONEER trial provides encouraging long-term data on avapritinib for indolent SM.

• Case report: New KIT mutation identified in a patient with SM

  A case report was recently published describing a man with systemic mastocytosis and a previously unknown KIT mutation.

• Researchers highlight complex mutational profile of SM-AHN

  Systemic mastocytosis with an associated hematologic neoplasm (SM-AHN) appears to have a higher mutational burden than isolated SM.

• Case report: Patient diagnosed with both SM and POTS

  A rare presentation of systemic mastocytosis (SM) alongside postural orthostatic tachycardia syndrome (POTS) was recently reported.

• Rare SM variant linked to new genetic mutations

  Well-differentiated systemic mastocytosis (WDSM), a rare SM variant, was recently associated with previously unknown genetic mutations.

• New study provides insights on how SM impacts the respiratory system

  SM is a risk factor for the development of respiratory symptoms, regardless of whether it presents as indolent SM or advanced SM.

• New program expands access to bezuclastinib for SM

  A new expanded access program (EAP) has been launched for patients with SM, allowing eligible patients to receive bezuclastinib.

• Phase 2 trial explores bezuclastinib for advanced systemic mastocytosis

  A Phase 2 clinical study called Apex is currently evaluating the safety and efficacy of bezuclastinib in patients with advanced SM.