Leonardo Jaimes, MD

All articles by Leonardo Jaimes, MD

• Patients who don’t meet all WHO criteria for SM can have same symptoms

  Patients with bone marrow mast cell infiltration who do not meet WHO criteria for SM can still have symptoms and are at risk for osteoporosis.

• Study underscores need for regular monitoring after indolent SM diagnosis

  A hematologist detailed several cases of SM that highlighted the need for diligence in diagnosing and managing treatment of ISM.

• Patients with indolent SM have quality of life comparable to that of some cancers

  Patients with indolent systemic mastocytosis appear to have a quality of life comparable to that of patients with lymphoma and leukemia

• Bezuclastinib improves SM symptoms significantly in clinical trial 

  A clinical trial demonstrated that bezuclastinib significantly improved symptoms and biomarkers of systemic mastocytosis.

• Ultrasensitive duplex sequencing improves SM diagnosis

  Ultrasensitive duplex sequencing could improve diagnosis of indolent systemic mastocytosis in patients with low variant allele frequencies.

• Bezuclastinib shows high overall response rates in patients with SM, company says

  Patients with systemic mastocytosis (SM) showed promising overall response rates to treatment with bezuclastinib, its maker announced.

• Some specialists have low awareness of SM, study says

  Some medical specialists lack awareness of systemic mastocytosis (SM) because of its association with various symptoms.

• Patients with SM have a distinct plasma protein profile

  Patients with systemic mastocytosis (SM) have a different plasma protein profile compared to healthy people.

• Bezuclastimib significantly reduced symptoms in nonadvanced SM: company

  Preliminary results showed that patients receiving bezuclastinib had better results than patients receiving a placebo in a clinical trial.

• Study will assess HMA and KIT inhibitors to treat SM subtype

  A new study will examine a treatment for patients with systemic mastocytosis with an associated hematologic neoplasm.