Ariana Boswell

All articles by Ariana Boswell

• Diagnosing SM: What is the Darier’s sign?

  The Darier’s sign is not a definitive test for SM, but it’s one of many tests that doctors may use to help get closer to a diagnosis.

• How does systemic mastocytosis affect the lungs?

  Abnormal and overactive mast cells can accumulate in many different areas of the body, including the lungs. 

• Understanding serum tryptase and systemic mastocytosis: What patients should know

  Mast cell activation causes tryptase to be released into the bloodstream, raising serum tryptase counts. 

• Researchers examine how SM affects mortality risk

  Advanced SM is associated with marked increases in five- and ten-year mortality, with nonadvanced SM also having impacts on mortality.

• Increased ST2 levels may be a biomarker of SM, study suggests

  ST2, a receptor that binds with interleukin-33, is elevated in patients with SM and may be a biomarker and future therapeutic target.

• What is urticaria pigmentosa?

  The primary method of managing urticaria pigmentosa involves avoiding your triggers.

• How to ‘Light Up for Rare’ on Rare Disease Day

  Landmarks worldwide will light up on Rare Disease Day.

• SM linked with increased risk of eclampsia in pregnancy

  A recent study found that having SM may increase the risk of eclampsia but decrease the risk of abortive outcome in pregnancy.

• Avapritinib remains effective in advanced SM after four years

  The PATHFINDER clinical trial demonstrated that avapritinib leads to durable treatment responses and a favorable risk-benefit profile.

• Case report: Child presents with MCL and ovarian cancer

  A 13-year-old female was diagnosed with mast cell leukemia, a type of SM, and stage IV ovarian mixed germ cell tumor.