News

Although systemic mastocytosis (SM) is typically mild in younger individuals, a recent case report shows that severe cases can still occur.

Systemic mastocytosis and related mast cell disorders may be identified more accurately with an updated REMA score algorithm.

Indolent SM can weaken internal bone structure and cause sudden spine fractures, even when standard density scans look completely normal.

Anti-CD117 CAR T cells achieved rapid and sustained killing of mastocytosis-related mast cells, exceeding 90% cell death in lab models.

A 55-year-old man with a type of blood cancer called acute myeloid leukemia was found to have mast cell leukemia after cancer treatment.

A failure to build CD8 central memory T cells may help explain why long-term tolerance is difficult to maintain after VIT in SM.

A case report abstract presented at AACE 2026 described a SM diagnosis made after a routine hypothyroidism referral.

Unlike adults with mastocytosis, most children with the condition don’t appear to be affected by low bone mineral density.

Non-D816 KIT mutations were associated with longer overall survival, lower mast cell burden and no cases of systemic mastocytosis.

New five-year data suggest venom immunotherapy may offer lasting protection against severe allergic reactions after insect stings.