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Caregivers reported emotional burnout and frequent logistic and systemic challenges when navigating healthcare for loved ones with ISM.

A variety of symptoms in nonadvanced SM are associated with a poor quality of life and show an unmet need for better symptom management.

Only 25% of patients with indolent SM report their disease is well controlled, despite most clinicians believing control is common.

In systemic mastocytosis, mast cells release substances that disturb the normal balance of bone health and can lead to osteoporosis.

A recent study found that having SM may increase the risk of eclampsia but decrease the risk of abortive outcome in pregnancy.

EtCC plays a significant role in downregulating immune responses, which is important in diseases such as systemic mastocytosis.

Measuring levels of a chemical in the blood called diamine oxidase during anaphylaxis could help doctors diagnose patients with hidden SM.

Researchers describe a case of acute myeloid leukemia relapse occurring five years after an allogeneic stem cell transplant for SM-AHN.

If approved, dibutepinephrine could offer patients with SM a needle-free epinephrine option that is easier to carry and use.

The PATHFINDER clinical trial demonstrated that avapritinib leads to durable treatment responses and a favorable risk-benefit profile.